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This study intends to biosynthesize gold nanoparticles (AuNPs) using  Amycolatopsis  sp. KMN and to investigate its potential antibiofilm, cytotoxic and antioxidant activities. The physicochemical characterization of biosynthesize AuNPs was identified by UV-Visible, energy-dispersive X-ray, and Fourier transform infrared spectroscopy, as well as high-resolution transmission electron microscopy, X-ray diffraction, zeta potential, and dynamic light scattering methods. Crystal violet assay and scanning electron microscopy showed that the AuNPs with a particle size of 44.4 nm have a strong antibiofilm activity (at 750 µg/ml concentration) against bacteria strains  viz Staphylococcus aureus  ATCC 29213,  Escherichia coli  ATCC 25922, and  Pseudomonas aeruginosa  ATCC 27853. The result also demonstrated strong cytotoxic activity against two cell lines, MCF-7 and HT-29. The MTT test result displayed that over a period of 48 hr, the IC 50  of AuNPs was 600 and 300 µg/ml for MCF-7 and HT-29 cell lines, respectively. The IC 50  of AuNPs against DPPH was 46.87 µg/ml. This is the first report that examines  Amycolatopsis  sp. strain KMN-mediated synthesis of AuNPs is rapid and  in situ  with antibiofilm and cytotoxicity activities. Moreover, it has the potential for an effective antibiofilm and cytotoxic activity that could be used in future therapeutic applications.

Antibiofilm and cytotoxic potential of extracellular biosynthesized gold nanoparticles using actinobacteria Amycolatopsis sp. KMN