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This review highlights the progress made in recent years in harnessing the peculiar chemistry of the hydroperoxyl, or perhydroxyl, radical (HOO • ) during lipid peroxidation, particularly with regard to its interaction with antioxidants. The HOO •  radical, the protonated form of superoxide, plays an important role in the propagation and termination of lipid peroxidation in nonaqueous systems. However, differently from alkylperoxyl (ROO • ) radicals that have only oxidizing ability, HOO •  has a two-faced oxidizing and reducing activity. The HOO •  radical can reduce the radical of the antioxidant (phenols and aromatic amines) by H-atom transfer (A •  + HOO •  ⟶ AH + O 2 ) thus increasing the length of the inhibition period and the effectiveness of the antioxidant. The simultaneous presence of HOO •  and ROO •  radicals triggers the catalytic antioxidant activity of quinones and nitroxides and explains the antioxidant activity of melanin-like polymers. The HOO •  radical can be formed by fragmentation of ROO •  radicals deriving from amines, alcohols, substituted alkenes and may be present at low concentrations in many oxidizing systems. Pro-aromatic compounds, like the natural essential oil component γ-terpinene, are the most effective sources of HOO •  and behave as co-antioxidants in the presence of nitroxides or quinones. The future developments and applications of HOO •  chemistry in the context of the inhibition of autoxidation are also discussed.

Hydroperoxyl radical (HOO • ) as a reducing agent: unexpected synergy with antioxidants. A review