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The present study  reports a novel technique to synthesise silica nanoparticles through modified sol-gel, ultrasonication, and hydrothermal routes. Physio-chemical and structural characterization was carried out using X-ray diffraction, high resolution scanning electron microscopy, energy dispersive spectroscopy, dynamic light scattering, Fourier transform infrared spectroscopy, ultraviolet-visible, and photoluminescence spectroscopy. The particle size determination revealed the spherical structure of nanoparticles with an average diameter of 85 nm and between 90-170 nm through HRSEM and DLS respectively. Stretching and vibration bands confirming the presence of SiO 2  were obtained in FTIR analysis. Spectra from UV-vis and PL spectroscopy were obtained at a maximum wavelength of 233 nm and 555 nm respectively. The anti-microbial effect of SiO 2  nanoparticles against  E. coli and S. aureus  bacteria revealed the appreciable response which renders them for many biomedical applications like drug delivery. The cytotoxicity of SiO 2  nanoparticles on human lung epithelial (A549) cell line revealed their non-toxic behavior.

materials technology

Structural, optical, cytotoxic, and anti-microbial properties of amorphous silica nanoparticles synthesised via hybrid method for biomedical applications