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Superparamagnetic Fe 3 O 4  has created major attention towards the drug delivery applications because it is used as the nanocarrier for delivering drugs to the specific tumour site and has less toxicity. The present report reveals a pH-responsive superparamagnetic iron oxide (Fe 3 O 4 ) nanoparticle comprising with Polyethylene glycol-polymethyl methacrylate (PEG-PMMA) as a drug carrier. This magnetite nanoparticle is prepared by the hydrothermal method and characterized. The synthesised nanoparticles are uneven morphology in shape and with varying in diameter range of 30−150 nm. .  In vitro  curcumin loading and its releasing behaviour of magnetic nanoparticles were analysed using a UV-Vis spectrophotometer. The obtained result shows that curcumin was liberated in a well sustained manner particularly in the pH 5.4, which is well suited for a human body for delivering drugs. The synthesised nanomaterials were treated against adenocarcinoma gastric cell line (AGS). Cur-PEG-PMMA-Fe3O4 persistently repressed the progress of AGS cells in a dose and time-dependent manner.

materials technology

Multifunctional polyethylene glycol-polymethyl methacrylate comprised magnetic nanoparticles as pH-responsive smart cargo for specific curcumin delivery