English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This work studied the effect of content of starch on the structure and properties of hydrogels generated by semi-interpenetrating the polysaccharide in the collagen-polyurethane matrix and generating biomaterials in the hydrogel state potentially useful in biomedicine. Starch increased the reticulation of the polymeric matrix by hydrogen bonding with the collagen fibers. The maximum swelling degree was observed for the formulation containing 40 wt.% of starch. The microstructure of these materials is semi-crystalline and the increase of the content of starch avoids the segregation of starch granules in the matrix, generating homogeneous surfaces that tend to release less glucose-rich degradation by-products and encapsulated ketorolac. Materials with low content of starch (10–20 wt.%) improve both the mechanical and thermal stability of the hydrogels and the ketorolac release performance. The matrices activated the metabolism of monocytes and fibroblasts, favoring their proliferation. The presence of starch in semi-IPN hydrogels confers high inhibition capacity of  E. coli  and a slow rate of hydrolytic and proteolytic degradation. The results of cell signaling for important cytokines in the wound healing process indicated that the CS20% matrix shows favorable modulation of TNF-α, MCP-1, and TGF-β secretion, so it could be successfully applied in the treatment of chronic wounds.

journal of macromolecular science, part a

Effect of the content of starch on the biocompatibility, bacterial inhibition, and drug release performance of semi-IPN collagen-polyurethane hydrogels