English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Antibacterial polyurethanes as wound-dressing material with high biocompatibility and thermal stability were developed from polyethylene glycol-200 (PEG200), 4,4′-methylenebis(cyclohexyl isocyanate) (HMDI) and β-cyclodextrin (βCD). βCD was preferred in this material because of providing biocompatibility and supporting the absorption/desorption characteristics of ciprofloxacin due to its hydrophobic gap. The β-cyclodextrin-PEG based polyurethane structures (PU-200-βCDs) was synthesized with different β-cyclodextrin:PEG:HMDI ratios. PU-200-βCDs were characterized by FTIR spectroscopy, thermal analysis, SEM, and water contact angle techniques. The biocompatibility property of polyurethane materials was determined according to the indirect cytotoxicity assay results and the PU-200-βCDs exhibited cell viability ranging from, 83.04 ± 7.28% to 99.73 ± 10.3% against L-929 cells. The hydrolytic degradability test was applied to the highest biocompatible PU-200-βCD3 structure. The mass loss of PU-200-βCD3 was determined 4.75 ± 0.86% at the end of the 28-day. Antibacterial properties of ciprofloxacin doped PU-200-βCD3 were investigated using  Escherichia coli  and  Bacillus subtilis . The ideal polyurethane structure was selected according to its biocompatibility and antibacterial properties. This polyurethane structure was converted into wound dressing material via electrospinning technique. The obtained dressing material showed mechanical stable fiber structure. Therefore, prepared β-cyclodextrin-PEG-based polyurethane structure can be suitable for the production of wound-dressing material due to its good ciprofloxacin release properties, high stability and biocompatibility.

journal of macromolecular science, part a

Fabrication, thermal and  in vitro  behaviors of ciprofloxacin loaded β-cyclodextrin-PEG based polyurethanes as potential biomaterial for wound dressing applications