English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Chitosan is a polyfunctional biomaterial that is subjected to chemical modification through functionalization to give the derivatives of remarkable anticancer activity. In this study, functionalization of low molecular weight commercial chitosan (CS) (Mw &lt; 3000 Da, 87% DDA) and high molecular weight crab shell chitosan (CCS) (viscosity average Mw 350 kDa, 67% DDA) as chitosan thiophene-2-thiosemicarbazones (DS 63.48–64.14%) and the formation of their copper(II) complexes were established by FT-IR,  13 C NMR, EPR spectroscopy, powder X ray diffraction, elemental microanalysis and magnetic susceptibility measurements. The thermal study of the compounds showed a substantial stability up to 200°C until the commencement of chitosan chain degradation. The MTT assay revealed higher activity of CS (IC 50  370 μgmL −1  in MCF-7 and &gt;400 μgmL −1  in MDCK cell line) than CCS (IC 50  &gt; 400 μgmL −1  in both cell lines), higher activity of CSTHPTSC (IC 50  364 μgmL −1  in MDCK and 369 μgmL −1  in MCF-7 cell line) than CCSTHPTSC (IC 50  &gt; 400 μgmL −1  in both cell lines), higher activity of the complexes Cu-CSTHPTSC (IC 50  338 μgmL −1  in MDCK and 318 μgmL −1  in MCF-7 cell line) and Cu-CCSTHPTSC (IC 50  293 μgmL −1  in MDCK and &gt;400 μgmL −1  in MCF-7 cell line) than their corresponding ligands.

Chitosan functionalized thiophene-2-thiosemicarbazones, and their copper(II) complexes: synthesis, characterization, and anticancer activity