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Some might expect the promise of ending a global pandemic via vaccination to interrupt conventional partisan media effect processes. We test that possibility by bringing together sentiment-scored COVID vaccine stories ( N  &gt; 17,000) from cable and mainstream news outlets,  N  &gt; 180,000 Vaccine Adverse Event Reporting System (VAERS) reports, and six original surveys ( N  = 6,499), in order to investigate (1) whether partisan news outlets covered COVID vaccination in different ways, and (2) if differences in coverage increased vaccine hesitancy. We find that Fox News’ (FXNWS) coverage was significantly more negative than that of other cable and mainstream sources, and is associated with increased negative public vaccine sentiment. In the aggregate, adverse event reports tended to increase following periods of heightened negativity on FXNWS. At the micro-level, self-reported FXNWS exposure is associated with increased vaccine refusal. Collectively, the results provide new insights into the public health consequences of vaccine politicization.

The Effects of Partisan Media in the Face of Global Pandemic: How News Shaped COVID-19 Vaccine Hesitancy