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We investigated the anti-ulcer activity of ethanol extracts of  Polygonum cognatum  on indomethacin induced gastric damage in rats. We evaluated the number of ulcer areas, oxidant and antioxidant parameters as well as histopathologic features in rat stomach. We measured the total antioxidant status of  P. cognatum  in concentrations from 1.56–100 mg/ml.  P. cognatum  extract inhibited indomethacin induced ulcer formation with an effect similar to a 20 mg/kg dose of the standard anti-ulcer drug, esomeprazole. All doses of  P. cognatum  extract exhibited positive effects on oxidative stress markers and histopathological features in the stomach tissue of rats. We suggest that the antioxidant activity of  P. cognatum  extract may be responsible for its gastroprotective effect and that  P. cognatum  extract may be a useful gastroprotective agent.

Effects of Polygonum cognatum Meissn. extract on indomethacin induced gastric damage in rats