English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The antimalarial activity of different parts (leaf, fruit, stem, and root) of  Phyllanthus amarus  and their associated impact on surrogate markers of insulin sensitivity in experimental mice, having ascertained their toxicity (LD 50 ) index were documented. Results showed that the plant parts were nontoxic (LD 50  &gt; 5,000 mg kg −1 ) and were antimalarial in a dose-dependent manner, with the ethanol leaf extract having the highest parasite suppression followed by the fruit, root, and stem extracts. However, the root extract had the most profound impact on insulin sensitivity compared to other parts, although all showed improvement, with insulin sensitivity/resistance indices, with QUICKI  vs . HOMA-IR showing a strong positive correlation (r = 0.993), but QUICKI  vs . HOMA-IR and HOMA-IR  vs . 1/HOMA = IR having strong negative correlation (r = −0.963 and −0.927, respectively). So, QUICKI and 1/HOMA-IR are surrogate indices of insulin sensitivity and HOMA-IR and TyG index, insulin resistance surrogate markers.

Antiplasmodial Activity of Phyllanthus amarus and Associated Impact on Surrogate Markers of Insulin Sensitivity and Resistance Indices