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CNVs (copy number variations) are the novel and common structural variants that could cover entire genes found in plenty of species. CNV may influence economically important traits or disease susceptibility in livestock species. Based on the whole genome resequencing results, we found that there was a CNV region on the  LRRFIP1  gene. Then we used qPCR to detect the copy number type distribution in 553 individuals of four sheep breeds and used them for association analysis. The results showed that: (1) In the CKS, the sheep with gain type had a larger heart girth ( p  = 0.049). (2) For the HS, the CNV could significantly affect rump breadth ( p  = 0.037) and circumference of the cannon ( p  = 0.035). And the sheep with median type showed better performance in rump breadth and circumference of cannon. (3) At the STHS, the CNV was significantly correlated with chest width ( p  = 0.000) with loss type as the most favorable CNV type. Meanwhile, the best was the loss type, and the lowest was the median. (4) This CNV had no significant effect on the LTHS. So, the CNV of  LRRFIP1  was related to the growth traits of these three sheep breeds and it may be used as a molecular marker for sheep.

Copy number variations of LRRFIP1 gene and the relationship with growth traits in four Chinese sheep