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N6-methyladenosine (m 6 A), the most abundant internal mRNA modification in eukaryotes, plays a vital role in regulating adipogenesis. However, its underlying mechanism remains largely unknown. Our previous study found that  ADRB1  gene has m 6 A modification in both muscle and fat tissue. In this study, we interfered with  FTO  and  ADRB1  genes After we cultured rabbit preadipocytes respectively. Oil red O staining and triglyceride assay were used to detect adipocyte differentiation. RT-qPCR was used to detect gene expression level and MeRIP-qPCR was used to detect the m 6 A modification level of gene. The results showed that  FTO  promoted the differentiation of adipocytes. At the same time,  FTO  up regulated the expression of  ADRB1  gene and down regulated the m 6 A modification level of  ADRB1  gene. Finally, we found that  ADRB1  inhibited adipocyte differentiation. Together, we showed that  FTO  promoted adipocyte differentiation by regulating  ADRB1  gene through m 6 A modification.

FTO promoted adipocyte differentiation by regulating ADRB1 gene through m 6 A modification in Hycole rabbits