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Diacylglycerol acyltransferase 2 (DGAT2) is the key enzyme that catalyzes the last step of triglyceride synthesis. However, its role in intramuscular fat (IMF) deposition in goat remains unclear. The purpose of this study was to explore the role of DGAT2 in regulating goat IMF deposition. In the present study, the expression of  DGAT2  was highest in goat triceps brachii, and highest on the first day after oleic acid induction in goat intramuscular preadipocytes. The overexpression of  DGAT2  promoted the accumulation of lipid droplets and triglyceride synthesis, accompanied by the expression upregulation of  DGAT1 ,  TIP47 ,  ACC  and  ACOX1  significantly, and expression downregulation of  AGPAT6 ,  LPIN1 ,  LPL ,  HSL ,  ATGL  and  ADRP  significantly. In contrast, the silencing of  DGAT2  decreased the accumulation of lipid droplets, inhibited the expression of  DGAT1 ,  GPAM ,  ADRP ,  AGPAT6 ,  LPL ,  HSL ,  ATGL, ACC ,  FASN ,  ACOX1  significantly, and enhanced that of  TIP47  significantly. Overall, these data underscore DGAT2 may play a potentially important role in lipid droplets formation and triglyceride accumulation, so as to maintain intramuscular fat deposition, beyond triglyceride synthesis in goat.

Diacylglycerol acyltransferase 2 promotes the adipogenesis of intramuscular preadipocytes in goat