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The objective of this study was to explore single nucleotide polymorphisms (SNPs) and gene expression of immune and antioxidant markers associated with reproductive disorders in Baladi goats. A total of one hundred adults Baladi does were allocated into two equal-sized groups: normal reproductive performance and does have a history of reproductive disorders. DNA sequencing of  PRLR  (304-bp),  LTF  (904-bp),  TLR2  (420-bp),  TLR4  (335-bp),  CLA-DRB3.2  (285-bp),  SOD3  (735-bp),  CAT  (1526-bp),  GPX4  (782-bp), and  GST  (690-bp) revealed SNPs associated with reproductive disorders tolerance/susceptibility in investigated does. Nonetheless, DNA sequencing of  beta defensin  (483-bp),  CCL5  (840-bp), and  ATOX1  (374-bp) genes elicited a monomorphic pattern. Levels of  PRLR ,  LTF ,  TLR2 ,  TLR4 ,  CLA-DRB3.2 ,  beta defensin , and  CCL5  genes were significantly up-regulated in does affect with reproductive disorders than tolerant ones; while  SOD3 ,  CAT ,  GPX4 ,  GST  and  ATOX1  genes pattern elicited an opposite trend. The results herein confirmed the potential significance of SNPs in immune and antioxidant genes as genetic markers for reproductive disorders tolerance/susceptibility in Baladi does. The Gene expression profile of investigated genes could be also used as proxy biomarkers for the prediction of the most susceptible risk time for disease occurrence and for building up an effective management protocol.

animal biotechnology

DNA polymorphisms and expression profile of immune and antioxidant genes as biomarkers for reproductive disorders tolerance/susceptibility in Baladi goat