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The  fibroblast growth factor 10  ( FGF10 ) gene regulates adipogenesis and myogensis. In this study, sequencing of  FGF10  prompter region identified three SNPs at loci g.78G &gt; A, g.116C &gt; T and g.201A &gt; T. Each SNP yields three genotypes as GG, GA and AA at loci g.78G &gt; A, CC, CT and TT at loci g.116C &gt; T and AA, AT and TT at loci g.201A &gt; T. Allelic and genotypic frequencies of all three SNPs deviated from the Hardy–Weinberg equilibrium (HWE) ( P  &lt; 0.05) and were found highly polymorphic as PIC (0.25 &lt; PIC &lt; 0.50). Moreover, we found highest LD (D′/γ2) between SNP2 and SNP3 (0.989/0.909), followed by SNP1 and SNP3 (0.944/0.796). Moreover, three variants of FGF10 gene promoter exhibited significant (P &lt; 0.05) association with body measurement and carcass quality traits in Qinchuan beef cattle. At loci g.78G &gt; A, the genotype GG showed significantly (P &lt; 0.01) larger body length (BL), rump length (RL), chest depth (CD), chest circumference (CC) and ultrasound loin area (ULA). The genotype TC at loci g.116C &gt; T showed significantly ( P  &lt; 0.01 and 0.05) larger body measurement and intramuscular fat, and ultrasound loin area (ULA). In addition to that, at loci g.201A &gt; T, genotype TT showed significantly (P &lt; 0.01 and P &lt; 0.05) larger body length (BL), rump length (RL), hip width (HW), chest circumference (CC) and ultrasound loin area (ULA). Additionally, screening of promoter sequence of  FGF10  gene explored loss of four TFs binding sites ( KLF3 ,  ZNF37α ,  GLIS2  and  BCL11A ) at g.116C &gt; T because of SNP2. However, a single TF binding site was lost at g.202A &gt; T due to SNP3. Interestingly, none of TF binding site was lost at g.78G &gt; A in SNP1; however, one new TF binding site was gained at this location due to SNP1. These findings conclude that genotype GG, TC and TT could be used as genetic markers of  FGF10  gene for body measurement and carcass quality traits in Qinchuan beef cattle.

animal biotechnology

Bioinformatics and genetic variants analysis of  FGF10  gene promoter with their association at carcass quality and body measurement traits in Qinchuan beef cattle