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Egl-9 family hypoxia-inducible factor ( egln ), an oxygen-sensing enzyme family, has been thoroughly characterized in mammals and certain fishes, but there is few research on its involvement in reproductive development and hypoxic stress in rainbow trout. In this study, we investigated the gene structure, physicochemical properties, and evolutionary connection of the  egln  gene family. The expression profile of  egln  gene family and their regulatory mechanism were explored using bioinformatics analysis and hypoxia treatment experiments. Five  egln  genes were discovered in the rainbow trout genome in this investigation ( egln1 ,  egln2a ,  egln2b ,  egln3a , and  egln3b ). Domain prediction revealed that all  egln  proteins have p4hc conserved domains, and phylogenetic analysis revealed that rainbow trout  egln2  and  egln3  were closely related to  Atlantic salmon . The results of real-time quantitative PCR (RT-qPCR) showed that  egln  genes were generally expressed in all detected tissues, and higher in the ovary, testis, and brain in normoxia. Under hypoxia, the expression level of  eglns  was significantly down-regulated in most tissues except the liver. Our research contributes to future research on the functional properties of  egln  genes, as well as the evolution of teleosts and the impact of hypoxia on biological immunity.

animal biotechnology

Evolution, characterization, and expression profile of Egl-9 family hypoxia-inducible factor ( egln ) in rainbow trout ( Oncorhynchus mykiss ) under hypoxia stress