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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 ( SERPINA3 ) belongs to the serine protease inhibitor family A subtype, and contains 8 genes from  SERPINA3-1  to  SERPINA3-8 . Although the regulatory effects of these 8 genes have been revealed one by one in recent years, the related effects of  SERPINA3-1  gene on cattle growth is still unclear. This study used quantitative Real time PCR (qPCR) to detect the type of copy number variation (CNV) of  SERPINA3-1  gene in a total of 542 Chinese cattle, and expression of  SERPINA3-1  gene in different tissues of Qinchuan cattles (adult) on mRNA level. Then association analysis was conducted between the detection results and cattle growth traits. The results showed that the Duplication type in  SERPINA3-1  gene performed better on the growth traits and the CNV was significantly correlated with multiple growth traits ( p  &lt; 0.05). In addition,  SERPINA3-1  gene has different expression conditions in different tissues, results showed that  SERPINA3-1  gene has a low expression in muscle. In conclusion, we speculate that the  SERPINA3-1  gene can be used as a molecular marker and the result of this study could be a basic material for candidate functional genes for beef cattle growth and development.

Association between copy number variation of SERPINA3-1 gene and growth traits in Chinese cattle