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Protein tyrosine phosphatase non-receptor type 3 ( PTPN3 ), a member of the membrane-associated non-receptor protein tyrosine phosphatase ( PTP ) family, plays significant roles in the cytoplasm and affects the development and growth of skin and hair. A recent study identified the  PTPN3  as the potential gene related to sheep wool quality. To detect single-nucleotide polymorphisms (SNPs) of  PTPN3 and  elucidate its association with wool production and growth traits in fine wool sheep a total of 644 healthy SG (South African mutton merino♂ × Gansu alpine fine-wool sheep♀, SG) and SSG (South African mutton merino♂ × SG♀, SSG) hybrid sheep were selected. Pooled-DNA sequencing and SNPscan methods were used to scan and genotype SNPs within  PTPN3 . Association analyses between SNPs and wool production and growth traits were implemented. Consequently, the results revealed that  PTPN3  has six SNPs (two missense mutations, one synonymous mutation, and three intron mutations), of which four loci (SNP2, SNP3, SNP4, and SNP5) were significantly positively correlated with growth and wool traits ( p  &lt; 0.05). SNP4 was significantly ( p  &lt; 0.05) linked with thigh wool length, and SNP6 was significantly ( p  &lt; 0.05) associated with abdomen wool length. Moreover, one strongly linked SNP block was identified to be correlated with wool production and growth traits (body weight and body size). The significant SNPs founded by this study could serve as useful genetic markers for breeding fine-wool sheep. ®

Association of SNPs within PTPN3 gene with wool production and growth traits in a dual-purpose sheep population