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Fibroblast growth factor 1( FGF 1) has been proved to bind to specific signal molecules and activate intracellular signal transduction, leading to proliferation or differentiation of cells. However, the role of  FGF 1 in goat adipocytes is still unclear. Here, we investigated its role in lipogenesis of goats, which depends on the activation of FGFRs. In goat intramuscular and subcutaneous adipocytes, we observed that adipocytes accumulation was inhibited by interfering of  FGF 1, the expression of  C / EBP α,  C / EBP β,  LPL ,  Pref -1,  PPAR γ,  AP 2,  KLF 4,  KLF 6,  KLF 10 and  KLF 17 were significantly down-regulated ( p  &lt; 0.05). When the  FGF 1 was up-regulated, the opposite result was found, while the expression of  C / EBP β,  LPL ,  PPAR γ,  SREBP 1,  AP 2,  KLF 4,  KLF 7,  KLF 15,  KLF 16 and  KLF 17 were increased significantly ( p  &lt; 0.05) in goat intramuscular and subcutaneous adipocytes. The expression level of  FGFR 1 was significantly and decreased with the interference of  FGF 1, and increased with the overexpression of  FGF 1. But in goat subcutaneous adipocytes, only the expression of  FGFR 2 was consistent with the expression of  FGF 1. Interference methods confirmed that  FGFR 1 or  FGFR 2 and  FGF 1 have the similarly promoting function in adipocytes differentiation. With the co-transfection technology, we confirmed that  FGF 1 promoted the differentiation of intramuscular and subcutaneous adipocytes might via  FGFR 1 or  FGFR 2, respectively.

FGF1 promotes the differentiation of goat intramuscular and subcutaneous preadipocytes