English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study aimed to analyze the effects of polymorphisms in  GP5  on blood physiological indices of 1065 sheep. The coefficients of variation of the red blood cell count (RBC), hemoglobin concentration (HGB), mean platelet volume (MPV), mean erythrocyte hemoglobin content (MCH), and red blood cell distribution-coefficient of variation (RDW-CV) were greater than 10%, and there was a very significant correlation between the main indices such as RBC, white blood cell, and platelet count (PLT) and most other indices ( p &lt;  0.01). qRT-PCR showed that  GP5  was expressed in the heart, liver, spleen, lung, kidney, rumen, duodenum, muscle, tail fat, and lymph tissue, with significantly higher expression in the lymph. Subsequently, we detected single nucleotide polymorphisms (SNPs) in  GP5  from group, which identified synonymous mutation g.657 T &gt; C in the first exon of  GP5 . Association analysis showed significant correlations between the SNP and the physiological traits ( p &lt;  0.05), in which the RBC, neutrophilic granulocyte (NEUT) and RDW-CV values in sheep with the  TC  genotype and  TT  genotype were markedly lower than those in the  CC  genotype ( p &lt;  0.05). Thus,  GP5  polymorphisms could be candidate biomarkers to screen blood physiological indices.

Polymorphisms in the ovine GP5 gene associated with blood physiological indices