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KLF7 b elongs to the Krüppel-like factors (KLFs) family, which function as transcriptional regulators controlling a number of basic cellular processes, involving proliferation, differentiation, and migration. Here, we reveal insights into the differentiated expression of  KLF7  in different goat tissues and different stages of growth, and the inhibition role of  KLF7  knockdown to differentiation by using goat intramuscular and subcutaneous preadipocytes. We demonstrate that  KLF7  expression is obviously changed during the differentiation of preadipocytes into mature adipocytes. Knockdown of  KLF7  inhibited lipid droplet accumulation, reduced the expression of adipogenic markers both in intramuscular and subcutaneous preadipocytes in goats, suggesting that  KLF7  is a novel regulator of adipogenesis.  KLF7  expression changed also up or down-regulation the other KLF family members, but there were differences between these two types of cells. Investigation into the mechanism that  KLF7  regulates preadipocyte differentiation revealed that KLF family members  KLF1 ,  KLF5 ,  KLF6 ,  KLF8 ,  KLF11 ,  KLF12 ,  KLF16 ,  KLF17  and adipogenic markers  C/EBPα  and  SREBP1  promoter region present KLF7 transcriptional binding sites. Altogether, the data here identify  KLF7  as a novel regulator of adipogenesis.

Knockdown of KLF7 inhibits the differentiation of both intramuscular and subcutaneous preadipocytes in goat