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Heat stress affects the animal production and causes serious economic losses to the husbandry. Tectonin beta-propeller repeat containing 2 ( TECPR2 ) gene plays an important role in autophagy which may affect the temperature sensation in animals. A missense mutation (XM_024981840.1:c.3989 G &gt; A p.Arg1330His) of the transcripts X4 in the bovine  TECPR2  gene was identified. In this study, the c.3989 G &gt; A variant in  TECPR2  gene was genotyped in a total of 25 cattle breeds (520 individuals). Our results indicated that the frequency of A allele showed a decreasing pattern from southern cattle to northern cattle, while the frequency of G allele showed the opposite pattern, which was consistent with the climate distribution of China. Compared with the GG genotype, southern cattle carried more the AA and AG genotypes. Furthermore, the association results carried out that the frequencies of genotypes (GG, AG, AA) and the value of climate parameters (mean annual temperature (T), relative humidity (RH) and temperature humidity index (THI) were significantly correlated ( p  &lt; 0.01). Hence, we speculated that the c.3989 G &gt; A variant of  TECPR2  gene was associated with the heat tolerance trait in Chinese cattle and the locus may be considered as a molecular marker for Chinese cattle breeding.

A novel SNP of TECPR2 gene associated with heat tolerance in Chinese cattle