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This study was conducted to explore the effects of dietary ferulic acid (FA) supplementation on intestinal antioxidant capacity and intestinal barrier function in weaned piglets. Eighteen 21-day-old castrated male DLY (Duroc × Landrace × Yorkshire) weaned piglets were randomly divided into control, 0.05% FA, and 0.45% FA groups, respectively. The experiment lasted for 5 weeks. The results showed that dietary 0.05 and 0.45% FA supplementation significantly increased catalase activity ( p  &lt; 0.001), the protein levels of nuclear factor E2-related factor 2 (Nrf2) and NAD(P)H quinone dehydrogenase 1 ( p  &lt; 0.05), and the mRNA levels of  superoxide dismutase 1 ,  glutathione reductase  and  Nrf2  ( p  &lt; 0.05) in jejunum when compared with the control group. Dietary 0.05% FA supplementation also increased the mRNA level of glutathione S-transferase ( p  &lt; 0.05) in jejunum. Meanwhile, Dietary 0.05 and 0.45% FA supplementation significantly increased the protein expression of zonula occludens 1 (ZO-1) ( p  &lt; 0.05), and dietary supplementation of 0.05% FA increased the mRNA levels of  ZO-1 ,  zonula occludens 2 ,  mucin 1 ,  mucin 2 ,  occluding , and  claudin-1  ( p  &lt; 0.05) in jejunum. Together, our data suggest that dietary 0.05% FA supplementation improves the intestinal antioxidant capacity and intestinal barrier function of weaned piglets.

Dietary ferulic acid supplementation improves intestinal antioxidant capacity and intestinal barrier function in weaned piglets