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Assisted reproductive technique like  in vitro  fertilization has contributed immensely in producing genetically improved livestock. Production of embryos under  in vitro  conditions can affect global DNA methylation pattern during the course of embryonic development. The present study is aimed at the generation and comparison of global DNA methylome of embryos at 2-cell, 8-cell and blastocyst stage of buffalo embryos produced by  in vitro  fertilization using MeDIP-Sequencing. It is observed that there is a profound difference in the global DNA methylation profile of IVF embryos at different developmental stages. These differences are manifested throughout the course of embryonic development. Pathways like Wnt signaling pathway, gonadotropin-releasing hormone receptor pathway and integrin signaling were found to be majorly affected by hypermethylation of DNA in IVF embryos throughout the development.

MeDIP-sequencing for profiling global DNA methylation in buffalo embryos produced by in vitro fertilization