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The  BMPRIB  gene is one of the main genes that can be used as a molecular genetic marker for the early selection of highly productive ewes. It is well-documented that the p.Q249R (g.746A &gt; G) is the first mutation in the kinase domain of the  BMPR1B  gene that is highly related to increased ovulation rate and litter size. It is likely that the presence of the p.Q249R mutation in the sheep population is one of the factors contributing to the outstanding productivity of the sheep. Moreover, in recent years, researchers have been explored other polymorphisms in the  BMPR1B  gene with respect to reproductive traits in sheep. Therefore, we carried out the current study to evaluate the association between polymorphisms in this gene and sheep litter size from all appropriate studies. As a result, among 41 polymorphisms in the ovine  BMPRIB  gene, eight variants, including p.Q249R (g.746A &gt; G), g.29362047T &gt; C, g.29427689G &gt; A, BMPR1B-2 (ss:1960972599), g.29382337G &gt; A, g.29382340G &gt; A, rs1092293287 (10 bp insertion/deletion) and g.29380965A &gt; G were found to be associated with litter size in sheep. This systematic analysis presents the most current data evidence for  BMPRIB  polymorphisms, highlighting the need for further large-scale studies to determine more important variants.

Survey of the relationship between polymorphisms within the BMPR1B gene and sheep reproductive traits