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The present study was undertaken to elucidate the direct ALA effects on mice TM4 Sertoli cells proliferation  in vitro . Our results showed that TM4 cells viability was significantly stimulated by ALA ( p &lt;  0.05). The 50 μM ALA increased the concentration of total antioxidant capacity, induced the mitochondrial membrane hyperpolarized, and markedly decreased the number of apoptosis cells ( p &lt;  0.05). ALA also up-regulated G2/Mitotic-specific cyclin-B1 gene and apoptosis suppressive gene  Bcl2  expression ( p &lt;  0.05). In conclusion, those results indicated that ALA could increase TM4 Sertoli cells antioxidant capacity, induced the mitochondrial membrane hyperpolarized, inhibited cells apoptosis and stimulated TM4 Sertoli cells proliferation  in vitro .

α-Linolenic acid induced TM4 Sertoli cells proliferation and enhanced total antioxidant capacity