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AMH ,  KISS1R  and  GDF9  genes play a vital role in human and animal reproduction and might be used as the genetic markers for the reproduction traits selection. The aim of this study was to screen the single nucleotide polymorphisms (SNPs) within the  AMH ,  KISS1R  and  GDF9  genes and to determine the correlations between these SNPs and the litter size in goats. Nine single SNPs within these genes were used for genotyping of the 190 Dazu black goat populations by SNaPshot technique. The polymorphisms of nine SNPs within these genes were detected in Dazu black goats. The significant correlation was observed between one SNP (g.89172108A &gt; C) within the  AMH  gene and the litter size of second born in Dazu black goats ( p  &lt; 0.05). The SNP was located in exon 4 (XM_018050765.1) of the  AMH  gene and was one nonsynonymous substitution, which resulted in a change of an amino acid from Glutamine to Proline (Gln38Pro). These results suggested that the nonsynonymous SNP g.89172108A &gt; C of  AMH  gene could be used as a potential genetic marker for Marker-assisted selection (MAS) in goats breeding programs.

A nonsynonymous SNP within the AMH gene is associated with litter size in Dazu black goats