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In our study, four single nucleotide polymorphisms (SNPs) were identified in exon 2 of  cofilin-1  ( CFL1 ) gene in 488 Chinese Qinchuan (QC) cattle, which included two missense mutations T 2084G and G 2107C, two synonymous mutations T 2052C and T 2169C. Further, we evaluated haplotype frequency and linkage disequilibrium (LD) coefficient of four SNPs. At SNP T 2052C, G 2107C and T 2169C, the QC cattle population belonged to intermediate genetic diversity (0.25 &lt;  PIC -value &lt; 0.5), whereas SNP T-2084G belonged to low polymorphism ( PIC -value &lt; 0.25). Haplotype analysis showed that 6 different haplotypes (frequency &gt; 0.03). LD analysis showed that SNP G 2107C and T 2169C, SNP G 2107C and T 2084G were high LD, respectively ( r2  &gt; 0.33). Association analysis indicated that SNP T 2052C was significantly associated with body length, chest breadth, chest depth and body mass in the QC population ( p  &lt; 0.01 or  p  &lt; 0.05). SNP G 2107C was significantly associated with rump length ( p  &lt; 0.05). SNP T 2169C was significantly associated with chest breadth and chest depth ( p  &lt; .01 or  p  &lt; .05). The results of our study suggest that the  CFL1  gene may be a strong candidate gene that affects growth traits in the QC cattle breeding program.

The polymorphism of bovine Cofilin-1 gene sequence variants and association analysis with growth traits in Qinchuan cattle