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Taurine upregulated gene 1 (TUG1) has been implicated in the onset and progression of various malignancies. The current study aimed to evaluate the biological function and potential mechanisms of TUG1 in multiple myeloma (MM) progression. TUG1 knockdown in MM cells was investigated  in vitro  and  in vivo  to evaluate the role of TUG1. We also predicted the transcription factor (TF) that bound to TUG1 together with the downstream target genes of the TUG1-TF interaction, and evaluated the regulatory mechanism of TUG1 in cell assays. TUG1 knockdown reduced the cell’s proliferative and migratory capabilities while increasing apoptosis and bortezomib sensitivity  in vitro  and inhibiting tumorigenesis  in vivo . TUG1 was found in the nucleus of MM cells and was found to be positively regulated by the TF-YY1. Further  in vitro  mechanistic investigations indicated that the YY1-TUG1 complex targeted YOD1 to regulate MM progression.

YY1-induced LncRNA-TUG1 elevates YOD1 to promote cell proliferation and inhibit bortezomib sensitivity in multiple myeloma