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Coagulation disorders increase mortality rate during septic shock, but the impact of concomitant hematological malignancies remains unknown. The study assessed coagulation disorders in onco-hematological patients with thrombocytopenia (&lt;100 G/L) admitted to ICU for septic shock. Among 146 included patients, 50 patients had lymphoma and 49 patients had acute leukemia. ICU mortality rate was 43.8% ( n  = 64). Median increase in prothrombin time (PT) at day(d) 1 was 4.7 s (IQR 3.2–7.9) in ICU survivors  vs.  6.4 s (IQR 4.5–13.7;  p &lt; 0.01 ) in non-survivors. Fibrinogen kinetics (increase in fibrinogen levels between d1 and d2) was +0.55 (−0.22–1.55)  vs.  +0.10 g/L (−0.40–0.50;  p = 0.03 ) in surviving and non-surviving patients, respectively. PT increase ≥6 s at d1 (OR 5.5; 95% CI 1.1–6.0;  p = 0.03 ) and mechanical ventilation (OR 7.4; 95% CI 3.3–17.7;  p &lt; 0.001 ) were independently associated with ICU mortality. This study provides information and new ways to identify hematological patients with high-risk mortality.

Sepsis-associated coagulopathy in onco-hematology patients presenting with thrombocytopenia: a multicentric observational study