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Comparative studies between total body irradiation (TBI)-based and busulfan-based myeloablative conditioning (MAC) regimens for cord blood transplantation (CBT) have been limited. We retrospectively analyzed the results of single-unit CBT in 333 adult patients who received either TBI-based ( n  = 258) or busulfan-based ( n  = 75) MAC regimens at our institute. After adjusting for significant variables in the univariate analysis, there were no significant differences in neutrophil recovery (hazard ratio (HR), 0.88;  p  = .460), grade III–IV acute graft-versus-host disease (GVHD) (HR: 1.40,  p  = .410), extensive chronic GVHD (HR: 0.73,  p  = .380), relapse (HR: 0.61,  p  = .270), non-relapse mortality (HR: 1.38,  p  = .420), overall survival (HR: 1.18,  p  = .637), or event-free survival (HR: 1.08,  p  = .773), although platelet recovery was lower with marginal significance for the busulfan-based regimen (HR: 0.67,  p  = .068). In subgroup analysis, TBI-based regimens were superior to busulfan-based regimens in terms of survival for acute lymphoblastic leukemia, but not for myeloid malignancies. Further investigation is warranted even for CBT.

Total body irradiation-based versus busulfan-based myeloablative conditioning for single-unit cord blood transplantation in adults