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A series of 1-[2-(4-methyl-2-(methylthio)pyrimidine-5-carboxamido)phenyl]ethyl-substitutedphenyl carbamates ( 3a – 3i ) were designed and synthesized, using 4-methyl-2-(methylthio)pyrimidine-5-carboxylic acid, (2-aminophenyl)ethan-1-one, and substituted phenyl isocyanates as starting materials. Their structures were characterized by  1 H NMR,  13 C NMR, IR and HRMS. The  in vitro  fungicidal activities against  Sclerotinia sclerotiorum  were evaluated, and the result showed that some compounds displayed moderate antifungal activity with &gt;60% inhibitory rates, among which 1-[2-(4-methyl-2-(methylthio)pyrimidine-5-carboxamido)phenyl] ethyl-(2- methyl phenyl)carbamate ( 3a ) and 1-[2-(4-methyl-2-(methylthio)pyrimidine-5- carboxamido)phenyl] ethyl-(3-trifluoromethyl phenyl)carbamate ( 3g ) held inhibitory rates of 69.5% and 70.3% at 100 mg/L, respectively. Molecular docking study showed that  3g  can form two hydrogen bonds and a cation-π interaction with succinate dehydrogenase.

Synthesis and fungicidal activity of 2-(methylthio)-4-methylpyrimidine carboxamides bearing a carbamate moiety