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This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. In addition, several compounds caused cytotoxicity at high cell densities. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.

A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985