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A new series of novel α-aminophosphonate derivatives have been synthesized by new rapid and convenient approach, based on the stepwise one pot reaction of 2-hydroxyaniline, aromatic aldehydes and triethyl phosphite. The structures of all compounds have been identified by appropriate spectroscopic methods such as FTIR,  1 H,  13 C,  31 P NMR and ESI-MS. The crystal structure of diethyl-(2-fluorophenyl)-(2-hydroxy-4-methylphenyl)amino phosphonate has been determined, it crystallizes in the  P -1 space group.  In vitro  antifungal activity of the synthesized compounds were tested against wheat fusarium ( Fusarium oxysporum ) and compared with standard antifungal drug Chlorpyriphos EC to explore their potential antifungal activity. We also measured the antioxidant activity of these molecules, compared with vitamin C as standard antioxidant.

A convenient synthesis, biological activity and X-ray crystallography of novel α-aminophosphonate derivatives