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A new series of organic tellurium compounds containing pyrazole derivatives were prepared. Initially, penta-2,4-dione-3-tellurocyanate ( 1 ) was prepared by the refluxing equimolar amounts of potassium tellurocyanate with 3-chloro-2,4-pentadione. Compound  1  was oxidized by excess bromine to obtain the corresponding tribromide ( 2 ). The cycloaddition reaction of compound  1  with phenylhydrazine formed 3,5-dimethyl-1-phenyl-4-tellurocyanatopyrazole ( 3  (in good yield. Treatment of compound  3  with excess bromine gave 3,5-dimethyl-1-phenylpyrazole-4-yltellurium tribromide ( 4 ) in an excellent yield. Reduction of compound  3  with a solution of 10% NaOH gave the corresponding ditelluride ( 5 ) in excellent yield. Compounds with a general formula of ArTeX 3 ; X = Cl ( 6 ) or I ( 7 ) were synthesized in excellent yields by reacting compound  3  with excess thionyl chloride or iodine, respectively. Refluxing ditelluride  5  with activated copper powder gave the corresponding telluride ( 8 ) in very good yield. Finally, tellurated pyrazole dihalides compounds  9–11  were prepared by reacting  8  with equimoles of the thionyl chloride, bromine and iodine, respectively. The structures of compounds  1 – 11  were elucidated according to their CHN elemental analyses and FTIR,  1 H- and  13 C-NMR spectroscopies and mass spectrometry. The antibacterial activity for both Gram-positive and Gram-negative bacteria were evaluated. The tested compounds showed a good degree against the growth of fungi and bacteria. Most the antimicrobial activity of the prepared compounds was better than fluconazole.

Convenient methods for the synthesis organotellurium compounds derived from pyrazole derivatives: synthesis and antimicrobial evaluation