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This short review article is dedicated to the Phosphonodithioformate-Amine Coupling (PAC) reaction. This reaction occurs by mixing phosphonodithioformate with amine without any catalyst and produces, according to a fast second order kinetics, phosphonothioamide. This reaction was applied to the functionalization of liposomes and opens new possibilities for the functionalization of synthetic or biologic materials.

Phosphonodithioformate-amine coupling reaction: from basic discovery to application for the functionalization of liposomes