English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A preparatively convenient one-pot method for the synthesis of new 7-thioxo[1,3]thiazolo[3,2- c ]pyrimidine derivatives  3a–3l  by the cyclocondensation of 5-methyl(1,3-thiazolidin-2-ylidene)ketones  1a–1c  with aroyl  2a–2d  and 2-thienyl  2e  isothiocyanates for 6–10 h boiling in acetone has been developed. Studies of the antimicrobial and antioxidant activities potential of the obtained compounds revealed that [2-methyl-5-(4-nitrophenyl)-7-thioxo-2,3-dihydro-7 H -[1,3]thiazolo[3,2- c ]pyrimidine-8-yl](phenyl)methanone  3k , effect on the test culture of  M. luteum  at a concentration of 0.5% is close to the control drug vancomycin. Moreover, [5-(4-bromophenyl)-2-methyl-7-thioxo-2,3-dihydro-7 H -[1,3]thiazolo[3,2- c ]pyrimidin-8-yl](phenyl)methanone  3j  has an antibacterial effect on the specified test culture at a minimum inhibitory concentration of 15.6 μg/mL. In turn, 1-(2-methyl-5-(thiophen-2-yl)-7-thioxo-2,3-dihydro-7 H -[1,3]thiazolo[3,2- c ]pyrimidin-8-yl]ethanone  3d  can be considered promising for further structural modification to enhance the antioxidant effect. The structure of all synthesized substances was established by spectral analysis ( 1 H and  13 C NMR, LC–MS, and FT-IR). Additionally, the structure of compound  3i  was confirmed by X-ray diffraction analysis.

phosphorus, sulfur, and silicon and the related elements

An efficient approach to the synthesis of 7-thioxosubstituted [1,3]thiazolo[3,2- c ]pyrimidines and evaluation of their antimicrobial and antioxidant activities