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In the present study, two types of starting compounds; hexachloro(N/O)-cyclotetraphosphazenes containing mono-ferrocenyl-pendant arm, namely, mono-ferrocenyl-2- cis -4-dichloro-ansa-(2,4-ansa;  2 ) and mono-ferrocenyl-spiro-(spiro;  3 ) were prepared by the reaction of N 4 P 4 Cl 8  ( 1 ) with sodium 3-( N- ferrocenylmethylamino)-1-propanoxide ( L ). Reactions of 2,4-ansa ( 2 ) with excess benzylamine and  n- hexylamine resulted in the formation of partly substituted 2- cis -4-dichloro-ansa-cyclotetraphosphazenes ( 2a  and  2b ). In contrast, spiro ( 3 ) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes ( 3a  and  3b ) with excess benzylamine and n-hexylamine. As expected, the 2,4-ansa cyclotetraphosphazenes ( 2 ,  2a,  and  2b ) have two distinct stereogenic P-centers. The structures of cyclotetraphosphazenes were evaluated by elemental analysis, ESI-MS, FTIR,  1 H,  13 C, and  31 P-NMR techniques. The antibacterial and antifungal activities against some selected bacteria and yeast strains, antituberculosis activities against  Mycobacterium tuberculosis  H37Rv, and DNA cleavage activities of mono-ferrocenyl-cyclotetraphosphazenes were also discussed. Compounds  2b, 3a,  and  3b  exhibited antifungal activity against  C. albicans  (MIC= 156.3 µM) higher than reference antibiotic Ketoconazole. Moreover, four compounds displayed antituberculosis activity against the  M. tuberculosis  H37RV. Compound  2a  (20 μg/mL) is the most potent of the four compounds.

phosphorus, sulfur, and silicon and the related elements

Phosphorus-nitrogen compounds. Part 56. Comparative syntheses and spectral properties of multiheterocyclic 2- cis -4-ansa and spiro-ferrocenyl (N/O)cyclotetraphosphazenes: Antituberculosis and antimicrobial activity and DNA interaction studies