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This work investigated the chemical composition of essential oils (EOs) obtained from the aerial parts of three  Inula  species of the Tunisian flora as well as their biological properties.  Inula viscosa  essential oil (IVEO) contained mainly  α -costic acid (65.4%). The EOs of  Inula graveolens  (IGEO) and  Inula crithmoides  (ICEO) were characterized by high contents of  p- cymene derivatives while ICEO stands out by high levels of modheph-2-ene (16.5%) and tiglic esters (14.1%). Moreover, a notable antioxidant power was proved by the ORAC test for the three EOs. Finally, the cytotoxic activity was evaluated on two healthy cell lines (CCD45-SK, HUVECs) and two cancer cell lines (HepG-2, MCF-7) and it appeared that the EOs were particularly effective on MCF-7 human breast cancer cells with LC 50  equal to 79, 16, and 63 µg. mL −1  for IVEO, IGEO, and ICEO, respectively.

Phytochemical profile and biological effects of essential oils from three Inula species grown in Tunisia