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This study aimed to determine the chemical composition, antibacterial and anti-inflammatory activities of  Melaleuca leucadendra  leaf essential oils. Ten samples of leaves from  M. leucadendra  were collected on the salt zone of Fatick (Senegal). The corresponding oils were obtained by hydrodistillation and analyzed by GC/FID and GC/MS. Oil yields from dried leaves were ranged from 1.64% to 2.75%. The almost exclusive compound in all samples of  M. leucadendra  oils was methyleugenol (98.4–99.5%). The oil exhibited moderate activity against  S. aureus  and  E. coli  and no activity against  E. faecalis and P. aeruginosa . Anti-inflammatory properties of oil (25, 100 and 150 mg/kg, bw) showed significant inhibition of rat paw oedema induced by carrageenan at the 3 rd  and 5 th  h (p &lt; 0.001 and 0.0001, respectively) when compared with control and standard drug (acetylsalicylic acid). The experimental study revealed that  M. leucadendra oil , a natural source of methyleugenol, displayed remarkable anti-inflammatory activity.

journal of essential oil research

The essential oil of  Melaleuca leucadendra  L. (Myrtaceae) from Fatick (Senegal) as a source of methyleugenol. Composition, antibacterial and anti-inflammatory activities