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Lonicera caerulea  is a honeysuckle plant with a long development history. It is defined as a "homology of medicine and food" fruit because it is rich in bioactive substances. By-products (such as pomace, leaves, stems, and flowers), which also have beneficial values, will be produced during processing. Nevertheless, the reuse of derivatives and the further development of new products of  Lonicera caerulea  are still a challenge. Firstly, this paper traced the development history of  Lonicera caerulea  and summarized its primary nutrients and bioactive substances, subsequently discussed the research progress and underlying molecular mechanisms of its functional properties, and introduced the application and potential of  Lonicera caerulea  in the fields of food, health products, cosmetics, medicine, and materials. Finally, this paper put forward the future research direction to promote the development of the  Lonicera caerulea  industry. To sum up,  Lonicera caerulea , as a potential raw material, can be used to produce more functional products. Besides, more in-depth clinical trials are needed to clarify the specific molecular mechanism of the practical components of  Lonicera caerulea  and improve the rate of development and utilization. HighlightsThe original species of  Lonicera caerulea  subgroup had appeared on the earth as early as the end of the third century.Lonicera caerulea  has been introduced into North America since the 18th century, but the introduction process has not ended until now.Lonicera caerulea  widely exists in Eurasia and North America and it has excellent cold tolerance, early maturity and ornamental.The fruits, stems, leaves and flowers of  Lonicera caerulea  all have bioactive value, but the specific molecular mechanism and utilization need to be improved.Lonicera caerulea  has been widely used in food, medicine, health products, cosmetics and materials, but there are still great challenges. The original species of  Lonicera caerulea  subgroup had appeared on the earth as early as the end of the third century. Lonicera caerulea  has been introduced into North America since the 18th century, but the introduction process has not ended until now. Lonicera caerulea  widely exists in Eurasia and North America and it has excellent cold tolerance, early maturity and ornamental. The fruits, stems, leaves and flowers of  Lonicera caerulea  all have bioactive value, but the specific molecular mechanism and utilization need to be improved. Lonicera caerulea  has been widely used in food, medicine, health products, cosmetics and materials, but there are still great challenges.

critical reviews in food science and nutrition

Lonicera caerulea  ( Haskap  berries): a review of development traceability, functional value, product development status, future opportunities, and challenges