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Veterinary medicinal products (VMPs) are used for the prevention and treatment of diseases in animals. The safety and efficacy of these products must be proven by quality control tests. Special attention should be paid to veterinary antimicrobials medicines (VAMs), as changes in their potency can compromise pharmacotherapeutic treatment and contribute to microbial resistance. The aim of this work was to review the analytical methods available for assessing the quality of VAMs, to analyze regulatory issues and quality control programs. The review was performed on selected papers in the PubMed, ScienceDirect, Scopus and Virtual Health Library databases, between 2005 and 2020. After applying exclusion criteria, 19 studies were obtained. Of the analytical studies, the majority (61.54%) used the HPLC technique. In addition, methods by CE (15.39%) and by SPM, FIA and microbiological assay (7.69% each) were found. In studies of monitoring of VAMs available on the market, changes in tylosin, spiramycin, ampicillin, tetracyclines and penicillins were observed. This is worrying, as these quality deviations can contribute to the development of resistant microorganisms. Although international efforts have been implemented at the regulatory level to ensure the quality of VAMs, it was realized with this study that there is much to evolve in the development of new analytical methods and in monitoring the quality of VAMs. With this, it is expected that this study will instigate scientists in the analytical, regulatory, microbiological and veterinary fields to develop new research so that the demands necessary to guarantee the quality of VAMs are increasingly met.

Analytical Methods for the Quality Control of Veterinary Antimicrobials Medicines