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In this research, new derivatives of spirooxadiazepines were prepared using multicomponent reactions (MCRs) of ninhydrin, secondary amines, Melderum’s acid, carbonyl compounds such as aldehyde or ketones and hydrazonoyl chloride in water at room temperature in the presence of baker’s yeast as catalyst in good yields. The short time of reaction, high yields of product, and easy separation of them are some advantages of this procedure. Another work in this research is investigation of antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping experiment. Presently, bacteria that are not destroyed with drug have generated many problems in the performance of many transferable disease. For this reason, discovering appropriate and new procedures for the dealing with these pathogens are important and recent study have focused on the investigation of the antibacterial effects on the prepared compounds.

Baker’s Yeast Promoted Facile Synthesis of Spirooxadiazepines Using Multicomponent Reactions of Ninhydrin: Investigation of Biological Activity