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A green protocol for diastereoselective synthesis of  trans -trans-1 H -Chromeno[2,3- d ]pyrimidine-2,4,6(3 H )-trione was applied by tandem aldol-Michael reactions between 1,3-dimethylbarbituric acid, aldehydes, and dimedone at room temperature on the water as well as the present of KF/Stilbite nanoparticles. Also, the catalytic activity of the nanocatalyst (NC) was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the NCs have very high and effective catalytic activity for organic pollutants within a few seconds. Antioxidant abilities of synthesized compounds were revealed using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiments. The compounds  4a–d  had excellent DPPH •  radical scavenging. Also, the antimicrobial activity of some synthesized compounds was proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria.HIGHLIGHTSSynthesis of diastereomer derivatives is important in medicinal chemistry. This research was designed for easy synthesis of diastereoisomer derivatives of 1 H -chromeno[2,3- d ]pyrimidine-2,4,6(3 H )-triones.The heterocyclic compounds have a recognized subject due to having a wide range of medicinal properties. The synthesized compounds revealed biological activities.Zeolites have cation replacement. Stilbite (ST), a natural zeolite with a framework structure and high internal surface area, is more effective because of its exchange capability for cations particularly for Na +  and Ca 2+ . Therefore, stilbite was used as a catalyst. Synthesis of diastereomer derivatives is important in medicinal chemistry. This research was designed for easy synthesis of diastereoisomer derivatives of 1 H -chromeno[2,3- d ]pyrimidine-2,4,6(3 H )-triones. The heterocyclic compounds have a recognized subject due to having a wide range of medicinal properties. The synthesized compounds revealed biological activities. Zeolites have cation replacement. Stilbite (ST), a natural zeolite with a framework structure and high internal surface area, is more effective because of its exchange capability for cations particularly for Na +  and Ca 2+ . Therefore, stilbite was used as a catalyst.

polycyclic aromatic compounds

Diastereoselective Synthesis of  Trans -1 H -Chromeno[2,3- d ]Pyrimidine-2,4,6(3 H )-Trione Derivatives by KF/Stilbite Zeolite NPs as a Novel Heterogeneous Nanocatalyst and Evaluation of Their Antimicrobial and Antioxidant Activity