English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

An efficient method using ZnO(NPs) was used to synthesize derivatives of  s -substituted-1,2,4-triazoles with excellent yield. The structure of all newly formed triazoles was approved using the data extracted from their spectral and elemental analyses. Fifteen  s -substituted-triazole derivatives were tested for their antimicrobial activity and the results indicated that triazole derivative  15  recorded the highest antimicrobial activity against  Trichophyton mentagrophyte  followed by  Staphylococcus aureus  and  Bacillus cereus  with clear zone diameters of 30, 28, and 15 mm when compared with the traditional antibiotics, with minimal lethal concentrations of 16, 32, and 64 µg/ml, respectively. While compounds  13c ,  13b ,  13a  and  8a  exhibited considerable antimicrobial activity against Gram-positive pathogens including  B. cereus ,  S. aureus . The docking study for the most potent derivatives  8a ,  13a ,  13b ,  13c  and  15  against methicillin acyl-Penicillin binding protein 2a from methicillin-resistant  S. aureus  strain 27r at 2.60 A resolution (PDB: 1MWU) showed strong fit in the active site the methicillin acyl-Penicillin binding protein, especially for derivative  15 . Due to the horror caused by the Corona pandemic during the past two years, we docked the  s -substituted-1,2,4-triazole derivatives into the active site of SARS-CoV-2 main protease (6LU7). The docking result showed well-fitting and proper orientation of all triazole derivatives except the starting derivative  5 . The physicochemical properties, pharmacokinetics, and drug-likeness of the most active  s -substituted-1,2,4-triazole derivatives were studied using SwissADME. The results of computational studies and  in vitro  antimicrobial activity showed great agreement, in addition to the docking study of COVID-19 revealed the ability of triazole derivatives to fit in the active site of the protein, which made us recommend laboratory tests for these triazole derivatives to prove their inhibition efficiency.

Assessment of Newly Synthesized Triazole Compounds Using ZnO(NPs) as Antimicrobial Agents and Theoretical Studies for Inhibiting COVID-19