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The present article depicts the synthesis of the series of 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones and their antibacterial activity against the  S. aureus . 6-(1-arylmethanamino)-2-phenyl-4 H -chromen-4-ones ( 1a–1n ) were obtained via reductive amination reaction of 6-aminoflavone with various commercially available aldehydes. Synthesized compounds and 6-aminoflavone ( 1 ) were assessed for their antimicrobial activities against the  S. aureus . 6-aminoflavone ( 1 ) was found to have an MIC of 2 µg/mL. The compounds with side chains 4-fluorobenzyl ( 1a ), 4-chlorobenzyl ( 1b ), 4-nitrobenzyl ( 1e ), 4-methoxybenzyl ( 1g ) and (quinolin-2-yl)methyl ( 1n ) were found to have an MIC of 2 µg/mL. We have demonstrated that 6-(1-arylmethanamino)-2-phenyl-4 H -chromen-4-ones are easily accessible via reductive amination reaction. These compounds are found to have antibacterial effect against  S. aureus .

Molecular Docking Studies and Application of 6-(1-Arylmethanamino)-2-Phenyl-4 H -Chromen-4-Ones as Potent Antibacterial Agents