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In this study a new and procedure was reported for the synthesis of Ag/TiO 2 /Fe 3 O 4 @MWCNTs MNCs as a new heterogeneous organometallic catalyst. XRD, FESEM, EDX and TEM analysis were used for confirming the structure of synthesized nanocatalyst. The Ag/TiO 2 /Fe 3 O 4 @MWCNTs MNCs as a high performance catalyst was employed for the preparation of a new family of functionalized spiro pyrrolo[3,4-d]pyrimidine  via  the one-pot condensation reactions of ethyl 2,4-dioxo-4-arylbutanoate, ammonium acetate, isatin, primary amines and  tert -butyl isocyanide in water at room temperature. Also, antioxidant property of some prepared compounds was investigated using diphenyl-picrylhydrazine (DPPH) radical trapping experiment. Presently, bacteria that is not destroied with drug have generated many problems in the performance of many transferable disease. For this reason, discovering appropriate and new procedures for the dealing with these pathogens are important and recent study have focused on the investigation of the antibacterial effects on the prepared compounds.

Synthesis and Investigation of Biological Activity of New Spiro Pyrrolo[3,4-d]Pyrimidine Derivatives