English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The extensive pharmacological applications of the pyrazole-based compounds stimulated us to synthesize the highly functionalized, pyrazolylmalonyl diisothiocyanate derivative  (2)via  treating 2-((1,3-diphenyl-1 H -pyrazol-4-yl)methylene)malonyl dichloride  (1)  with ammonium thiocyanate in acetonitrile at room temperature. The diisothiocyanate derivative  2  was subsequently conducted with a double molar ratio of different nitrogen nucleophiles like 4-acetylaniline, 2-aminobenzoic acid, 6-aminothiouracil, 2-aminothiadiazole derivative, hydrazine, phenylhydrazine, thiophene-2-carbohydrazide, 2-hydroxybenzohydrazide, 2-cyanoacetohydrazide, thiourea, thiosemicarbazide, 2-aminoaniline, and thiocarbohydrazide, aiming to construct some valuable heterocyclic systems. The synthesized compounds were screened for their insecticidal activity against healthy late third instar larvae  P. interpunctella  and  Nilaparvata lugens  and the results showed that pyrimidinethione, thiadiazolotriazine, and tetrazinethione derivatives exhibited the highest insecticidal potency that are supported by DFT stimulation and their molecular docking.

polycyclic aromatic compounds

Synthesis, Density Functional Theory, Insecticidal Activity, and Molecular Docking of Some  N -Heterocycles Derived from 2-((1,3-Diphenyl-1 H -Pyrazol-4-yl)Methylene)Malonyl Diisothiocyanate