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Heterocyclic compounds are an essential part of drug design and discovery. The pharmaceutical industry uses and investigates nitrogen-containing heterocycles because they are crucial in discovering and developing novel therapeutic compounds. Due to their diverse pharmacological potentials, benzimidazole derivatives have been widely useful in medicinal chemistry over the past few decades. Similarly, indole derivatives also possess a wide range of biological potential. It is observed that compounds incorporating two or more structural moieties in a single hybrid structure are always known to have a wide range of pharmacological activities. Thus, the pharmacological properties of benzimidazole scaffolds can be improved by incorporating indole moieties. The present review demonstrates the recent development in pharmacology and structure-activity relationships of indole-benzimidazole hybrid derivatives. It may help researchers and computational chemists to find the lead structures associated with indole-benzimidazole in drug discovery and design.

Indole Fused Benzimidazole Hybrids: A Promising Combination to Fulfill Pharmacological Significance