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A new library of bis-thiazol-1,2,4-triazinehybrids having 1,3,4-oxadiazoles ( 10a–j ) has been designed and synthesized. They were examined for their preliminary anticancer properties against four selected human cancer cell lines including SiHa (cervix), A549 (lung), MCF-7 (breast) and Colo-205 (colon) by using of MTT method and etoposide selected as a positive control. Most of the compounds displayed remarkable anticancer activities. Amongst, the five compounds  10a, 10b, 10c, 10d,  and  10e  demonstrated the most promising activity. Predominantly, compounds  10a  and  10e  possessed a higher potent inhibitory effect toward three cell lines.

Design, Synthesis and Anticancer Evaluation of Novel Bis-Thiazol-1,2,4-Triazine Hybrids Contained 1,3,4-Oxadiazoles